Clinical Studies on Silybin Phytosome

Clinical Study – Ref16P23

Biochemical Pharmacology, Vol. 50 No. 8, pp. 1313-1316, 1995

Scavenging Effect of Silipide (Siliphos®), a new Silybin-phospholipid Complex, on Ethanol-Derived Free Radicals

A. Comoglio, A. Tomasi*, S. Malandrino**, G. Poli*** and E. Albano****

*Departments of Experimental Medicine and Oncology and Medical Sciences, University of Torino; ***C.N.R. Centre of Immunogenetics and Experimental Oncology, Torino; **Indena S.p.A. Milano and *Institut of General Pathology, University of Modena, Italy

See National Library of Medicine Citation

The results of this study indicate that (Silybin Phytosome) effectively scavenges hydroxhethyl radicals. However, this effect is lost when the same amount of pure silybin is administered instead. The ability of Silipide (Silybin Phytosome) to scavenge ethanol-derived radicals along with its antioxidant activity suggests that this drug might be potentially useful in counteracting free radical-mediated injuries involved in the development of liver damage caused by alcohol abuse.